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Phase III clinical data from SCENESSE trials (the FDA-approved formulation of afamelanotide) demonstrated that patients with erythropoietic protoporphyria achieved clinically meaningful photoprotection after 60 days of sustained drug delivery via controlled-release implant

Despite these findings suggesting a minimal direct influence of depression on glycemic control, this condition may still significantly heighten the risk of severe complications in diabetes [14], emphasizing the necessity for comprehensive management approaches that address both psychological and physiological aspects of diabetes care

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